Tuesday, April 14, 2015

Biomarker-based asthma phenotypes of corticosteroid response

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Inhaled corticosteroids (ICSs) are the mainstay of treatment of asthma. However, a considerable proportion of asthmatic patients do not res...
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Friday, April 10, 2015

Overweight children report qualitatively distinct asthma symptoms: Analysis of validated symptom measures

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The relationship between overweight/obesity and asthma phenotype in children remains inadequately defined. Several large epidemiologic stud...
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Wednesday, April 8, 2015

The prevalence of severe refractory asthma

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Severe asthma is characterized by difficulty to achieve disease control despite high-dose inhaled glucocorticoids plus long acting β 2 –ago...
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Wednesday, March 18, 2015

Pioglitazone restores mitochondrial oxidant production in CGD phagocytes and enhances their bactericidal capacity

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In addition to having a nonfunctional NADPH oxidase, activated phagocytes from patients with chronic granulomatous disease (CGD) and gp91pho...
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Tuesday, March 17, 2015

Anti-IL-23A mAb BI 655066 for treatment of moderate-to-severe psoriasis: Safety, efficacy, pharmacokinetics, and biomarker results of a single-rising-dose, randomized, double-blind, placebo-controlled trial

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Psoriasis, a chronic immune-mediated inflammatory skin disease, affects approximately 2% of the global population. Eighty to ninety percent...
2 comments:
Monday, March 9, 2015

Allergy to furry animals: New insights, diagnostic approaches, and challenges

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The prevalence of allergy to furry animals has been increasing, and allergy to cats, dogs, or both is considered a major risk factor for th...
3 comments:
Wednesday, March 4, 2015

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

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Recent years have seen a tremendous acceleration of knowledge in the field of glycobiology, revealing many intricacies and functional contr...
1 comment: