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Thursday, June 2, 2011

Psoriasis and atopic dermatitis: The same, only different

In the May issue of JACI, Guttman-Yassky et al. (J Allergy Clin Immunol 2011;127:1110-1118), in part 1 of a 2-part review, covered the clinical and pathological similarities and differences between psoriasis and atopic dermatitis (AD) with AD as the point of reference. They finish up in this month’s issue (J Allergy Clin Immunol 2011;127:1420-1432) with a broad discussion comparing the immune phenotypes and therapies for AD and psoriasis.

In part 1, Guttman-Yassky et al. pointed out that psoriasis and AD both present with defects in skin barrier function, skin lesions infiltrated by increased numbers of T cells and dendritic cells and upregulation of epidermal proliferation genes. They note that the chronic phase of AD is more similar to psoriasis than the acute phase. There are distinct differences though. AD patients are susceptible to bacterial and viral skin infections, which is not true for psoriasis patients. Also, AD skin is characterized by decreases in keratinocyte differentiation, cornification, moisture and lipid content. Though lipid depletion is also observed for psoriasis, it is characterized by increased differentiation and cornification. Cytokine milieu in AD is dominated by TH2 cells, while psoriasis is associated with TH1 and TH17 cytokines. Additionally, AD is associated with structural protein anomalies (e.g., filaggrin dysfunction) that are not observed in psoriasis.

The authors discuss in part 2 how the disorders were thought to be mediated by polarized T helper cell responses with TH2 dominance seen in AD; however, this simple dichotomy did not account for all observations, such as hyperkeratinization, seen in chronic AD. They point out that the discovery that TH17 and T22 cells affected epidermal activation eventually led to a new working model wherein psoriasis is mediated by TH1 and TH17 immunity, and AD is mediated by TH2 and T22 cell effects. Production of anti-microbial peptides (AMP) is known to be compromised in AD compared to psoriasis. This was originally attributed to the TH2 environment, but the authors comment that IL-17 deficiency as well as excessive TH2 cytokines can explain the decreased AMP production found in AD. Guttman-Yassky et al note that the impaired AMP production would explain increased susceptibility to skin infections in AD. In contrast, psoriasis is characterized by increased AMP production. The authors also discuss basic differences between AD and psoriasis with regard to differences in dendritic cell populations, AD-associated eosinophilia, barrier defects and inflammation, and mast cell production of interferon gamma (IFN-γ) in psoriasis.

Guttman-Yassky et al. finish up part II with a discussion of the prognosis and intervention for psoriasis and AD. Unlike AD, they note that active psoriasis can be completely resolved and treatment time is short. The authors comment that, in spite of their differences, both AD and psoriasis share epidermal hyperplasia, aberrant immunity, and skin barrier anomalies. This would suggest that immune-based strategies to correct barrier defects that have been developed for psoriasis might be effective for AD. Guttman-Yassky et al. detail current AD treatments and make a case for psoriasis therapies as intervention for AD.

Tell us what you think. Please feel free to post your own comments and/or predictions below.

40 comments:

  1. I don't know, there is much different option to try to heal your symptoms of psoriasis, but from your text I'm under impressions P it's not so dangerous disease, I'm not saying it's dangerous but it's quite ugly and something now one would have to have.

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  2. Personally I think that all these skin disorders are sun related..... exacerbated by some other skin irratant. When a person is diagnosed with psoriasis...this is such a broad term. I believe any person can develope psoriasis if exposed to the right catalysts....I also believe that many people develope actinic dermatitis in concert with other skin irratants(atopic dermatitis) and are just lumped into the "psoriasis" heap. From my personal experience "psoriasis" is a normal natural response to "something"

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  3. Fighting psoriasis can be a lifelong battle to find the right cure for psoriasis for you and one of the ways to fight psoriasis is to make important lifestyle changes as well as use home remedies for psoriasis. It is important to not lose hope in the fight against psoriasis which can happen after trying various approaches that may have worked for someone else but fail to work for you. You just need to keep experimenting until you find the right psoriasis treatment that works for you.

    Chasteberry Plus

    ReplyDelete
  4. Hello,

    I appreciate your idea here. Th17 lineage is a recently described subset of memory T cells that is characterized by its CD4+ status and its ability to make a constellation of cytokines including interleukin-17A, IL-17F, IL-22, and in humans, IL-26. Definitely it has a good content. Thank you for imparting more of your own thoughts...

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  5. Thanks for this great article…

    ReplyDelete
  6. This is very educational content and written well for a change. It's nice to see that some people still understand how to write a quality post!
    How to get rid of psoriasis

    ReplyDelete
  7. hello i want to used this opportunity to thank a great doctor oguba ogubaspellhealinghome@gmail.com who helped me to cured my psoriasis i was directed by sister who received healing from him also. i almost lose hope in life when my sister told me about this great doctor who has healed many people cure psoriasis and cure herpes virus , i thought it will require many things but by the special grace of God every thing was simple, now i am healed from psoriasis, i am now a normal human with out sickness. please my brothers and sisters if there is any one have same problem please remember to contact him now via email: ogubaspellhealinghome@gmail.com

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  9. my health restore
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    ReplyDelete
  10. As a sign of gratitude for how my husband was saved from psoriasis , i decided to reach out to those still suffering from this.
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    ReplyDelete
  11. As a sign of gratitude for how my husband was saved from psoriasis , i decided to reach out to those still suffering from this.
    My husband suffered psoriasis and it was really tough and heartbreaking for me because he was my all and the symptoms were terrible, we tried various therapies prescribed by our neurologist but none could cure him. I searched for a cure and i saw a testimony of so many people who was cured from psoriasis, and so many other with similar body problem, and he left the contact of the doctor who had the herbal cure to psoriasis . I never imagined psoriasis has a cure not until i contacted him and he assured me my husband will be fine. I got the herbal medication he recommended and my husband used it and in one months he was fully okay even up till this moment he is so full of life. psoriasis has a cure and it is a herbal cure contact the doctor for more info on dr.oseherbalspellhome@gmail. com on how to get the medication. Thanks for reading my testimony ......

    ReplyDelete
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  13. I can’t believe this is really true I never believe there is cure to this hsv 2 because all the hospital have told me there is no cure to it, few months ago I saw this man email DR.AZIEGBE on internet from a testimony share by someone who he help with his herbal cure I contact his email and ask for his help also, that is how he inform me about the cure process and this man sent me a herbal medicine which I took according to the way he instructed for 2 week I can’t believe when I go for test my result come out negative i am so happy to share this to the world there is real cure to herpes you can also contact DR.AZIEGBE through his email now DRAZIEGBE1SPELLHOME@GMAIL. COM and also WhatsApp him +2349035465208. or my assistant text me +1 (601) 452-8622 or email: JAMESAVA0001@GMAIL. COM...

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  14. I was diagnose with hpv virus for 5years i broke up with my boyfriend because i contracted the virus from him, luckily i found a herbalist name Dr. onokun everyone testify good of his natural treatment i picked up his address and contacted him. he truly treated me with natural herbs in a week and i got cured. i share this post because ever since i got this treatment I'm perfectly ok with my health. i contacted him through this email.. dronokunherbalcure@gmail.com

    ReplyDelete
  15. I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com or you can call or whatsApp his mobile number on +2348107855231.

    ReplyDelete
  16. I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com or you can call or whatsApp his mobile number on +2348107855231.

    ReplyDelete
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    ReplyDelete
  18. I got diagnosed with hpv, i have be dealing with this mess for the past 7yrs. On till i got review online about natural cure people testifies how they got cured with natural treatment. And i order the treatment, after taking it for two weeks i totally got cured with herbal treatment. I'm recommending you diagnosis with hpv should get this treatment via; dronokunherbalcure@gmail.com or whatsapp call.. +2349064844957

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  19. 5 years ago I had warts, I was treated with some liquid applied to the warts they continued to grow and spread... The next 2 doctors did laser surgery to remove them. 1 year after the surgery, they grew back close to where the 1st ones were' so I was finally told it was hpv. I have had it for very long time, I contract it from my cheated boyfriend and I found out he was also infected and I end up the relationship between us. the warts was so embarrasses because it started spreading all over I have be dealing with this things for very long time the last treatment I take was About 2 years ago I applied natural treatment from Dr onokun herbal cure, a week after applying the treatment all the warts was gone. it's now 2 years and some months I don't have single wart or any symptoms of hpv. wow"" it's great, Dr onokun has finally cured me. Anyone living with hpv contact Dr onokun for natural treatment.
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    ReplyDelete
  20. I has suffered for Human papillomavirus HPV) for 2years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr onokun is the most trustful herbalist that have herbs to cure wicked symptom's,I emailed dr onokun, for 2weeks been his patient he cured my (HPV) with his herbal. I only used his natural herbs for two weeks it was 100% cure. I'm not (HPV) patient anymore. I'm happy about it i finally got cured out of this mess been in my body for 2years. I also recommend you if you're living with (HPV) or herpes symptoms i also want you to be free contact dr onokun with the email attach to my post. dronokunherbalcure@gmail.com

    ReplyDelete
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  23. I’m from USA am here to give my testimony about Dr Robinson who helped me cure my HERPES (HSV), i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS), i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. Three months ago a friend suggested that I try herbal medicine; from a very powerful herbal doctor called (Dr.Robinson) I looked up his blog on the internet site and indeed he have had immense success with his product. There were lot of persons posting their testimony about how he cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, my HERPES result just came out negative. (Robinson.buckler (@ yahoo). com 🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂🙂 I must admit ( ( Robinson.buckler) ) is really a genuine man when it comes to getting an ex lover back

    ReplyDelete
  24. I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com. or you can call or whatsApp his mobile number +2348107855231.

    ReplyDelete

  25. I have been suffering from HIV and Genital Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr TAKUTA on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr TAKUTA today on this Email address: takutaspellalter@gmail.com or WhatsApp him on this Tell.Number +27788634102....

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    ReplyDelete

  26. I have been suffering from HIV and Genital Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr TAKUTA on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr TAKUTA today on this Email address: takutaspellalter@gmail.com or WhatsApp him on this Tell.Number +27788634102....

    Dr.TAKUTA also cures:
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    2. HERPES 1/2
    3.DIABETES
    4.STROKE.
    5.STDS and STI
    6. MARRIAGE COUNSELLING
    7.LOVE SPELL CASTING
    8.JOB PROMOTION SPELLS
    9.MARITAL PROBLEM
    10.MAGIC MONEY SPELLS

    ReplyDelete

  27. I have been suffering from HIV and Genital Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr TAKUTA on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr TAKUTA today on this Email address: takutaspellalter@gmail.com or WhatsApp him on this Tell.Number +27788634102....

    Dr.TAKUTA also cures:
    1. HEPATITIS A,B,C
    2. HERPES 1/2
    3.DIABETES
    4.STROKE.
    5.STDS and STI
    6. MARRIAGE COUNSELLING
    7.LOVE SPELL CASTING
    8.JOB PROMOTION SPELLS
    9.MARITAL PROBLEM
    10.MAGIC MONEY SPELLS

    ReplyDelete
  28. Hello! I'm very excited to inform everyone that I'm completely cured from my HSV 1&2 recently. I have used Oregano oil, Coconut oil, Acyclovir, Valacyclovir, Famciclovir, and some other products and it's really help during my outbreaks but I totally got cured! from my HSV with a strong and active herbal medicine ordered from a powerful herbalist and it completely fought the virus from my nervous system and I was tested negative after 12 days of using the herbal medicine. I'm here to let y'all know that herpes virus has a complete cure, I got rid of mine with the help of Dr Willams and his herbal exploit. Contact him via email: dr.harrissonwillams@aol.com and as well write him on WhatsApp +1 (213) 349-2159.

    ReplyDelete
  29. I am so glad to write this article today to tell the world how Dr Isibor cured me from HPV virus that have been in my body since five years ago, ever since then my life has been incomplete, i have used so many drugs that was prescribed to me by several doctors, but it didn’t cure my HPV VIRUS neither did it reduce the pain, i was checking for solution on the internet then miraculously came across Dr Isibor the powerful herbalist that cure HPV INFECTION, then i contacted his email, i explained everything to him and he prepared a herbal medicine and send it to me that was how i use it and got cured from HPV disease totally after receiving his herbal medicine, so my friends viewers why waiting and be suffering with this HPV virus when there is someone like Dr Isibor that can cure any kinds of disease such as HIV, CANCER, HEPATITIS C VIRUS, GENITAL HERPES VIRUS, PAPILLOMA, ALS VIRUS, MENOPAUSE SYMPTOMS. you can contact him via email: drisiborspellhome@gmail.com.

    ReplyDelete
  30. Thanks to great Dr Isibor that i met on this site. i am dana guerrie from California. i was an HPV victim. i had it for over four years i do visit hospital always before. I was just at the point of death with shame after i have lost everything in life even my love one until my close relative direct me to this site to look for great Dr Isibor . It so amazing to see my self back to my feet with everything i have lost. i am very happy because Dr Isibor did not only cure my sickness but he restructure my life by bringing back my ex and every thing i lost to the course of this sickness(HPV). i do not really know where to start from in appreciating you Dr Isibor. please my people out there do not play with your problem go out and seeks for the help of great Dr Isibor herbal healing, he healed me without future problem or hidden charges. now i am free from HPV and My husband, my joy and happiness are back. please with out a second choice go contact great Dr Isibor for the betterment of your life. CONTACT HIM VIA EMAIL;drisiborspellhome@gmail.comor whatsapp number +2348107855231

    ReplyDelete
  31. I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com. or you can call or whatsApp his mobile number +2348107855231.

    ReplyDelete
  32. Am very glad to share this testimony with everyone for the marvelous work Dr Isibor has done for my life, 5months ago i was diagnosed with herpes virus and ever since then i have been very unhappy, i was so down broken everyday, until one day when i came across a shocking testimony about how Dr Dr Isibor cured someone of his herpes virus, without wasting much time i contacted him immediately on his email address: drisiborspellhome@gmail.com and after i explain myself to him about how terrible i have been, and he assure me that he will help me to cure my herpes virus,after he has prepared the herbal medicine he sent it to me and when i have received it and started using it i was totally cure within 2weeks, i am forever grateful to Dr Dr Isibor for helping me out with his herpes prescription that cured my virus. contact his email address: drisiborspellhome@gmail.com or you can call or whatsApp his Mobile number:+2348107855231

    ReplyDelete
  33. I want to share a testimony of how Dr UDI herbal mixture cream saved me from shame and disgrace, my penis was a big problem to me as the size was really so embarrassing ,and i was also having weak erection problem i had so many relationship called off because of my situation, i have used so many product which i found online but none could offer me the help i searched for Which was very painful and then i saw some few testimonies about this herbal specialist called Dr UDI and decided to email him on so I gave his herbal product a try. i emailed him and he got back to me and we discussed, he gave me some comforting words and encouraged me also ans then gave me his herbal pills and cream for Penis Enlargement Within 1 week of it, i began to feel the enlargement of my penis, " and now it just 2 weeks of using his products my penis is about 10 inches longer and am so happy contact Dr UDI via (drudiherbalhome@gmail.com) Via whatapp on this number +2348051243538

    ReplyDelete
  34. In my life i have never thought herbal medicine could cured herpes. However it wouldn't have been possible for me to gain my health back without the kind support and help of doctor Isibor , i would like to extend my golden sincere thanks to doctor Isibor who helped me with his herbal medicine which he sent to me through DHL courier services. it is germane i start by introducing doctor Isibor the great herbalist doctor who is so powerful and good in herbal medicine to cure any kind of illness. I am highly indebted to doctor Isibor for his help in curing me of herpes with his herbs. Don't let anybody to deceive you because i am a living testimony. the different between Ordinary and Extra-Ordinary is the "Extra" My dear friends go for the Extra and regain your health back to normal again with doctor Isibor herbs. You can give it a try by purchasing doctor Isibor herbs through his whatsapp number: +2348107855231 or mail address::::: drisiborspellhome@gmail.com

    ReplyDelete
  35. 2 WEEKS AGO I ENDED NATURAL HERBAL TREATMENT FROM TRADITIONAL HEALER WHO IS IN AFRICAN, I GOT RID OF HPV VIRUS OUT OF MY BODY WITH HIS HERBAL TREATMENT. It SO AMAZING I'M FREE FROM THIS VIRUS FOREVER. YOU CAN REACH HIM ON; DRONOKUNHERBALCURE@GMAIL.COM

    ReplyDelete
  36. I was cured from my herpes Diseas. after suffering since 4years ago. but when i contact Dr uza on the internet. he gave me a Natural cure that ended my suffering after using it for two weeks. i went to check myself on the hospital and i was tested negative. I can't more happier but to say thank you sir and i use this medium to say to everyone don't waste any time to contact this powerful herbal Dr uza On any Kind of Disease he is Ready to help yeou. You can reach him through his email: druzaherbalcure@gmail.com

    ReplyDelete
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