There is evidence that the presence of asthma can influence
patients’ susceptibility to infections, yet research in this aspect of asthma
has been limited. Additionally, there is a debate in the field with current literature
tending to suggest an increased risk of infection among atopic patients as due to opportunistic infections secondary to airway
inflammation, especially in severe atopic diseases. Other evidence suggests
that such risk and its underlying immune dysfunction may be a phenotypic or
clinical feature of atopic conditions. In his review, Young J. Juhn argues that
improved understanding of the effects of atopic conditions on the risk of
microbial infections will bring important new perspectives to clinical
practice, research, and public health concerning atopic conditions [J Allergy Clin Immunol 2014; 134(2): 247-57].
The review focuses on the effect of atopic conditions on the
risk of infections, termed reverse causality. For example, asthma is associated
with a broad range of common and serious viral and bacterial respiratory tract
infections controlled by different types of immunity (e.g. Th1 or Th2).
However, given the association of atopic dermatitis and allergic rhinitis with
risks of such infections, the results may imply that immunologic dysfunctions
might have a role, while the structural alterations of airways observed in
asthma may also need to be taken into account. Furthermore, research suggests
that the effects of asthma on risk of infection may not be limited to the
airways but go beyond the airways, for example, patients with asthma have an
increased risk of contracting various types of herpes viruses. As effects of atopic conditions on the risks of various infectious diseases emerge, it will be increasingly necessary to address a broader range of patient care issues in the current guidelines. Also, the roles of allergists, immunologists, and pulmonologists may be broader in the future. This review provides insight into the foreseeable needs and challenges of the effects of atopic conditions.
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ReplyDeleteYou can reach him for complaints or know more about Dr. Elabe and get cure for once for any of your heath problems ..@
Emaile:dominicelabeherbalhome4all@gmail.com
Phone no:+2348140918600
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