Search This Blog

Tuesday, February 28, 2017

Humoral and cellular responses to casein in patients with food protein–induced enterocolitis to cow's milk

Food protein-induced enterocolitis syndrome (FPIES) is a type of food allergy in which children who eat milk, soy, or other foods develop repetitive vomiting and sometimes diarrhea.  This can lead to dehydration, and, in the longer run, failure to thrive.  But unlike more typical food allergies, FPIES isn’t mediated by IgE antibodies.  In fact, what causes FPIES is still a bit of a mystery.  In this month’s issue of JACI, Caubet and colleagues discuss results of their study on the immune responses seen in FPIES due to cow milk (CM-FPIES) (J Allergy Clin Immunol 2017; 139(2): 572-583).

To do this, they looked that the levels of antibodies, cytokines (chemical messengers), cell counts, and tryptase levels in 38 patients with active and resolved CM-FPIES.  Oral food challenges (OFCs) were performed, and the results from positive OFCs were compared to those from negative OFCs.

What they found is that neutrophils could be responsible cells, which were found to be higher in patients with positive oral food challenges.  The high levels of IL-8, a chemoattractant for neutrophils, also supported their conclusion.  Mast cells may also participate, since IL-9 that was also high is produced by mast cells, and baseline tryptase levels were elevated.  But interestingly, tryptase levels didn’t increase with the positive oral food challenge, meaning that mast cells weren’t activated during a challenge.  Regulatory cytokines, such as IL-10 are likely related to the development of oral tolerance in FPIES.  Additionally, levels of antibodies specific to casein, a key component of milk, were low in children with CM-FPIES.    There remain a lot of unanswered questions about FPIES, but this study helps to shine some light on this mysterious type of food allergy.

3 comments:

  1. I smoked for 20 years, October 2014 i was diagnosed of Emphysema my doctor told me there is no permanent cure for the disease, i was given bronchodilators to help me relax my bronchiolar muscles, I managed on with the disease till a friend told me about a herbal clinic from johannesburg who sell herbal medicines to cure all kind of diseases including emphysema, I contacted this herbal clinic via there email and made purchase of the emphysema herbal medicine, i received the herbal medicine through DHL within 5 days, when i received the herbal medicine i applied it as prescribed and was totally cured of emphysema within 7 weeks of usage, the symptoms reduced till i even forgot i had emphysema, i went back to my doctor for diagnosis with spirometry and he confirmed i was free from the disease, contact this herbal clinic via there email healthherbalclinic@gmail.com or website on www.healthherbalclinic.weebly.com

    ReplyDelete
  2. I smoked for 20 years, October 2014 i was diagnosed of Emphysema my doctor told me there is no permanent cure for the disease, i was given bronchodilators to help me relax my bronchiolar muscles, I managed on with the disease till a friend told me about a herbal clinic from johannesburg who sell herbal medicines to cure all kind of diseases including emphysema, I contacted this herbal clinic via there email and made purchase of the emphysema herbal medicine, i received the herbal medicine through DHL within 5 days, when i received the herbal medicine i applied it as prescribed and was totally cured of emphysema within 7 weeks of usage, the symptoms reduced till i even forgot i had emphysema, i went back to my doctor for diagnosis with spirometry and he confirmed i was free from the disease, contact this herbal clinic via there email healthherbalclinic@gmail.com or website on www.healthherbalclinic.weebly.com

    ReplyDelete
  3. Thanks to dr.ezomo for his good work I never believe that ALS has cure, I was ALS over 3 year now before I came across a comment about how
    dr.ezomo cure ALS and herpes disease but when I saw it i have it in mind
    that he cant cure ALS I just decided to give it a try I contact him that
    night luckily to me he replied me, but I dont believe him I thought it was
    a scam but I still hold on to see the work of Dr ezomo if he is saying the
    truth he ask for some details about me i gave him all he needed and I
    waited to see his reply to my problem after all, he told me to go for check
    up and I went for HIV test I cant believe I was negative,am so happy and
    grateful to God for using Dr ezomo to cure me, that is the reason why i
    decided to write this wonderful testimony of our i was cured, i recommend
    Dr ezomo to you all around the world,contact him on his Email dr.ezomorootandherbals@gmail.com or you can also reach him through WhatsApp number+2349069171173
    dr.ezomo for helping me at this young age if you need help contact,
    He can also cure so many sickness

    ReplyDelete