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Thursday, March 23, 2017

Body fat mass distribution and interrupter resistance, fractional exhaled nitric oxide, and asthma at school-age

Obesity and asthma are two of the most common childhood chronic diseases, seen in 25% and 10% of children, respectively.  There are increasing lines of evidence suggesting that they may be inter-dependent : fat may be the source of proinflammatory mediators and may change the mechanics of lung function. 

However, not all fat is considered equal.  The android distribution of fat along the abdomen, compared to gynoid distribution along the hips, is more closely associated with a variety of cardiometabolic diseases.  Similarly, visceral fat, situated just above the guts in the belly, is considered a marker of inflammatory status, compared to more superficial subcutaneous fat deposits.  In this month’s issue of JACI, den Dekker and colleagues discuss the effect of body fat mass distribution on asthma and airway function in children (J Allergy Clin Immunol 2017; 139(3): 810-816).

To do this, they looked at the medical histories and physical characteristics of 6178 children.  They focused on body-mass index (BMI), total and abdominal fat measures using ultrasonography and dual energy x-ray absorptiometry (DEXA), respiratory resistance (Rint), fractional exhaled nitric oxide (FENO), wheezing, and asthma.   They found that a higher BMI was associated with increased respiratory resistance and current wheezing.  They also noted that more visceral fat was associated with a higher FENO, while a higher android (belly)/gynoid (hip) ratio was associated with a lower FENO. 

Altogether, these results suggest that local fat deposition, especially visceral fat, is more closely related to asthma.  Even though the reasons for this are unclear, the authors speculate that maybe the different metabolic profiles of visceral vs. subcutaneous fat and the mechanical effects may be responsible for these differences.  Regardless, understanding the finer details of fat composition and distribution may help to explain part of the increased prevalence of childhood asthma.

1 comment:

  1. Asthma is a chronic health condition that affects the airways and lungs. It occurs when the airways and passages in the lung are inflamed and swollen, making it difficult for air to pass through them. The airways produce a thick mucus, which also blocks the passage of oxygen. This inflammation and mucus secretion can worsen because of triggers, such as allergies or exposure to pollutants and irritants. This causes the airways to constrict even more, resulting in symptoms such as coughing, wheezing, shortness of breath, and chest tightness. Together, all of these things make it difficult to breathe. For some people, these symptoms appear especially during exercise, when an additional strain is placed on the lungs to get enough oxygen. For others, symptoms of asthma only appear during exercise, a condition known as exercise-induced asthma. Other types of asthma include allergic asthma and occupational asthma. Asthma most commonly appears during childhood and last into adulthood, though it can also appear for the first time in adults over the age of twenty. Asthma tends to run in families—children with one or two parents who have asthma are more likely to develop asthma. Asthma is also closely linked to allergies. In many cases, allergies are triggers of asthma symptoms. Most people who suffer from asthma also suffer from allergies. I found out that there is a product to cure asthma which i use for my son, he is now living a better life. thanks to Dr ewoig. Though asthma has cure. for more informant email him on Drewoig18@gmail.com

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