Search This Blog

Monday, December 3, 2012

Standardizing research food challenges

A pressing need for standards of conduct for research-related double-blind, placebo-controlled, oral food challenges (OFC) provided the impetus for a consensus report by Sampson et al in this month’s issue (J Allergy Clin Immunol 2012;130:1260-1274).

After a brief review of the historical literature on diagnosing food allergy, Sampson et al present topical discussion summaries for major issues in the conduct of research OFC, noting that the guidance and recommendations apply equally to clinically performed challenges. The authors emphasize that patient/subject safety was the pre-eminent consideration. The following are highlights from their discussions:
·      Pre-challenge assessments. The authors cover important evaluations and practices prior to conducting OFC. These include case history, current food avoidance, comorbid conditions that impact safety such as atopic dermatitis and chronic disease, the utility of surrogate test results and their intrinsic problems, and the requirement for an optimal challenge setting. They also discuss the issue of differential severity of allergens as an important safety consideration prior to OFC.
·      Challenge procedures and assessments. Sampson et al discuss dosing schedules and their necessary variability tied to outcomes. General recommendations for dosing include low starting doses, separate active and placebo challenge days, dosing intervals no less than 20 minutes and appropriate, low fat matrices. Recording important, objective clinical parameters, such as respiratory symptoms and other physical reactivity symptoms, is covered. Sampson et al emphasize that scoring and stopping criteria must be pre-specified in light of the critical role of clinical judgment in OFC conduct. Delayed reaction considerations and subjective symptom issues are also reported. Tables of their recommendations are provided for reference.
·      OFC analysis and reporting. To ensure a reliable evidence base, Sampson et al provide guidance and recommendations for statistical analysis and reporting results, particularly from randomized trials. 


  1. The authors emphasize survival warehouse that patient/subject safety was the pre-eminent consideration.

    1. My lover is back with the great help of DR OKAYA who helped me cast a spell that brought him back to my arms, in just two days. My lover left me with our only kid and now they are back, once again i want to thank DR OKAYA for his wonderful spell am now a happy woman. you can contact the great spell caster on his email: for more help or you can still reach him on his phone number in person on call/Whatsapp +27814506790 for more advise

  2. This comment has been removed by a blog administrator.


  3. I have being hearing about this blank ATM card for a while and i never really paid any interest to it because of my doubts. Until one day i discovered a hacking guy called morris . he is really good at what he is doing. Back to the point, I inquired about The Blank ATM Card. If it works or even Exist. They told me Yes and that its a card programmed for random money withdraws without being noticed and can also be used for free online purchases of any kind. This was shocking and i still had my doubts. Then i gave it a try and asked for the card and agreed to their terms and conditions. praying and hoping it was not a scam i used the blank ATM CARD and it was successful i withdraw nor less than 10,000 dollar each every day the blank ATM CARD worked like a magic and now i have become rich and famous in my society, if you want to order for the blank ATM CARD here is there email address

    Here is our price list for ATM cards:
    $10,000 ------------- $800
    $20,000 ------------- $1,600
    $35,000 ------------$2,000
    $50,000 ----------- $2,400
    $100,000----------- $3,000